BIOACTION

Programming bacteria for infection treatment

BIOACTION aims at developing a new methodology in implant technology based on bio-hydrogels that will convert biofilm-associated infections, the primary cause of implant failure, into a positive resource. The project is programming implant-associated bacteria to produce specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages bound to hydrogel scaffolds. BIOACTION is also developing new biomimetic substrates that can transform biofilm into extracellular matrixes to regenerate target tissues. The project uses adaptable technology as injectable materials and implant coatings for periodontal and peri-implant infection treatments. The approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone. It could impact the future of infection treatment by revolutionizing classical methods to improve care and health outcomes, achieving substantial socio-economic benefits. The project involves expertise in biomaterials, synthetic biology, phage and liposome technology, and medicine. BIOACTION's innovative approach will push research and knowledge beyond state-of-the-art. It could also have a broader application in regenerative medicine.