A major obstacle in preventing high breast cancer mortality is the limited understanding of how breast cancer cells metastasise to bone sites. The EU-funded B2B project aims to develop a first-of-a-kind 3D model of spontaneous breast cancer metastasis to the bone for the purposes of basic research and drug screening in a physiological context. It will overcome the drawbacks of traditional in vitro and in vivo models by mimicking the physiological system of connected organs. Cultured breast cancer organoids will be connected in vitro to marrow-containing bone tissue via a fluidic system involving the self-assembled capillaries of those organoids and an artificial 3D bioprinted macro-vascular tree of branching blood vessels.
A quick overview of the goals achieved by working on this project.
Resilient and environmentally sustainable engineered crops to address climate change
Bacteria Biofilm as bio-factory for tissue regeneration
3D printing of ultra-fidelity tissues using space for anti-ageing solutions on earth
Printed symbiotic materials as a dynamic platform for living tissues production