H2020TRL 5-6Synthetic biology


Synthetic biology-guided engineering of Pseudomonas putida for biofluorination

Project details

GA Number



Research and Innovation Action


€8 m


1 January 2019


4 years

Microbial cell factories for fluorochemicals

Materials containing fluorine are essential in our modern world, with applications in electronics, healthcare, automotive and wearables. These fluorochemicals are currently exclusively synthesised using harsh chemical methods. The EU-funded SinFonia project aims to develop a more sustainable alternative by engineering the robust bacterium Pseudomonas putida to become a cell factory that makes fluorinated monomers and polymers. The project will produce fluorochemicals in these bacteria with metabolic engineering, circumventing the traditional chemical reactions used in industry. The target compounds are a family of fluorinated polyesters with enhanced physicochemical and material properties for self-cleaning surfaces, low surface energy coatings, bio-based lubricants, fuel cell membranes and anti-fouling materials.


Danmarks Tekniske UniversitetMax-Planck-Gesellschaft zur Förderung der WissenschaftenMasarykova univerzitaCourt & Senate Office University of St AndrewsAgencia Estatal Consejo Superior de Investigaciones CientíficasTartu ÜlikoolL'Université du LuxembourBioplastech Ltd.Biofaction KGAltarINsocietyifeu – Institut für Energie- und Umweltforschung Heidelberg gGmbHChemours Netherlands BV

Our role

What we did to make this project TRULY INNOVATIVE.

Innovation management, organization of exploitation plans, and Life Cycle Assessment.

The ambition of SinFonia is to set the stage for a future economically, ecologically and societally sustainable value chain for the production of novel, bio-based fluoropolymers from renewable substrates.